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Rescuvolin 15 mgTablet

বাংলায় পুন
Leucovorin [Folinic Acid]

Composition

Each Rescuvolin 15 mg film-coated tablet contains Leucovorin Calcium USP equivalent to Leucovorin (Folinic Acid) 5 mg.

 

Pharmacology

Calcium Folinate is a Calcium Salt of Folinic Acid (citrovorum factor), an active metabolite of Folic Acid, and an essential co-enzyme for nucleic synthesis used in Cytotoxic therapy.

 

Indications

Rescuvolin 15 mg tablet is indicated-

  • To diminish the toxicity and counteract the effects of overdosage of Folic Acid antagonists.
  • To treat Megaloblastic anemia due to folate deficiency, and nutritional deficiency. 
  • To treat the Megaloblastic anemia of pregnancy and infancy due to folate deficiency

 

Rescuvolin 15 mg Price in Bangladesh

Each tablet MRP is 68 tk and each box of 10 tablets is 680 tk.

 

Dosage and Administration

  • Reduction of harmful effects of folic acid antagonists: 5-15 mg tablet every 6 hours for 2 to 3 days.
  • Megaloblastic anemia: 5-15 mg tablet daily. Or as directed by the physician.

 

Contraindications

Folinic Acid is contraindicated for the following: 

  • Known hypersensitivity to Folinic Acid or any components of the product formulation.
  • Pernicious anemia or other Megaloblastic anemia where Vitamin B12, is deficient.

 

Warning & Precautions

  • Folinic Acid treatment may mask pernicious anemia and other Megaloblastic anemia. it is resulting from Vitamin B12, deficiency.
  • Folinic Acid should only be used with 5-fluorouracil or Methotrexate under the direct supervision of a clinician experienced in the use of cancer chemotherapeutic agents.

 

Side Effects of Rescuvolin 15 mg

There are some common side effects of Rescuvolin 15 mg which are not dangerous. The side effects are-

  • Allergic reaction-Like sudden itchy rash (hives) & swelling of the hands
  • Feet
  • Lips, mouth, or throat (which may cause difficulty in swallowing or breathing) Fits and fainting 
  • Ankles
  • Face.

 

Pregnancy & Lactation

There are no adequate and well-controlled clinical studies conducted on pregnant or breastfeeding women. It is not known whether this drug is excreted in human milk. As many drugs are excreted in human milk, caution should be exercised when Folinic Acid is administered to a nursing mother.

 

Children & Adolescents

There are no data available on children

 

Interactions

With Medicine:

  • Many Cytotoxic medicinal products direct or indirect DNA synthesis inhibitor-lead to macrocytosis (Hydroxycarbamide, Cytarabine, Mercaptopurine. Thioguanine). Such macrocytosis should not be treated with Folinic Acid.
  • in epileptic patients (treated with Phenobarbital, Phenytoin, Primidone, and Succinim ides), there is a risk of increasing the frequency of seizures due to a decrease in plasma concentrations of the anti-epileptic drug. 

With food & others:

  • There is no known interaction of Rescuvolin 15 with any kind of food.

 

Overdose

There have been no reported sequelae in patients who have received significantly more Folinic Acid than the recommended dosage. However, excessive amounts of Calcium Folinate may nullify the chemotherapeutic effect of Folic Acid antagonists.

 

Storage

Store in a cool & dry place, protected from light. Keep out of the reach of children.

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