Angivent MR 35 mg Tablet (Modified Release)

Composition

Each Angivent MR 35 mg tablet contains Trimetazidine Hydrochloride BP 35 mg.

Pharmacology

Trimetazidine Hydrochloride has been proven to exert antianginal properties due to its specific metabolic mechanism of action. Trimetazidine Hydrochloride reduces the metabolic damage caused during ischemia, by acting on a critical step in cardiac metabolism: fatty acid β-oxidation. This is made possible by selectively inhibiting an enzyme of fatty acid β-oxidation: the long-chain 3-ketoacyl CoA thiolase (3-KAT). This inhibition results in a reduction in fatty acid oxidation & stimulation of glucose oxidation. 

Thus, the coupling of glycolysis with glucose oxidation is improved, and ATP production is further increased, while the harmful consequences of acidosis and of Ca2+ overload are limited.

Indications

Angivent MR is indicated for long-term treatment of angina pectoris.

Angivent MR 35 mg Price in Bangladesh

Each Angivent MR tablet MRP is 8 tk and each box of 30 tablets is 240 tk.

Dosage and Administration

Trimetazidine dihydrochloride 35 mg twice daily or 20 mg three times daily during meals. After three months of consumption, should go again to the doctor.

Contraindications

Hypersensitivity to Trimetazidine Hydrochloride should not be used.

Side Effects of Angivent MR

Angivent MR is a well-tolerated drug. But there may be some immediate problems.

• Rarely urinary problems
• Nausea and vomiting
• Dizziness
• Headache
• Abdominal pain
• Diarrhea
• Dyspepsia
• Rash, 
• Pruritus, 
• Urticaria and asthenia

Drug interactions

No drug interactions. No interaction with beta-blockers, calcium antagonists, nitrates, heparin, hypolipidemic drugs, or digitalis in particular.

Pregnancy & Lactation

Pregnancy: Studies in animals have not demonstrated a teratogenic effect. However, in the absence of clinical data and for safety reasons, the prescription should be avoided during pregnancy. 

Breastfeeding: In the absence of data, breastfeeding is not recommended during treatment. 

Storage

Protect from light and moisture—store below 30° C. Keep the medicine out of reach of children.