A-Pak 100 mg Tablet

Indications

A-Pak 100 mg Tablet is prescribed for the relief of pain and inflammation associated with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, low back pain (lumbago), toothache, and soft-tissue injuries or trauma.

Pharmacology

A-Pak 100 mg is a non-steroidal anti-inflammatory drug (NSAID) with both anti-inflammatory and analgesic properties. It works primarily by inhibiting the enzyme cyclooxygenase (COX), which plays a key role in the synthesis of prostaglandins—substances responsible for pain, swelling, and inflammation. After oral administration, Aceclofenac is rapidly and completely absorbed and remains largely unchanged in the bloodstream.

Dosage & Administration

• Extended-release tablet: The usual adult dose is 200 mg once daily, or as directed by the physician.
• Film-coated tablet: The usual adult dose is 100 mg twice daily.

Interactions

No significant drug interactions have been commonly reported; however, careful monitoring is advised when Aceclofenac is administered with the following:

• Lithium or Digoxin: May increase serum concentrations of these drugs.
• Diuretics: May reduce the effectiveness of diuretic therapy.
  Anticoagulants: May enhance the anticoagulant effect, increasing the risk of bleeding.
• Methotrexate: May elevate plasma levels, increasing the risk of toxicity.

Contraindications

A-Pak 100 mg is contraindicated in patients with:

• Known hypersensitivity to Aceclofenac or other NSAIDs.
• A history of aspirin- or NSAID-induced asthma, urticaria, or allergic-type reactions.

Side Effects

Common side effects may include nausea, indigestion, abdominal pain, dizziness, rash, or headache. Gastrointestinal disturbances such as ulceration or bleeding may occur in sensitive individuals or with prolonged use.

Pregnancy & Lactation

A-Pak 100 mg tablet should be avoided during pregnancy and breastfeeding, unless the potential benefit to the mother clearly outweighs the possible risks to the fetus or infant.
Use only on medical advice.

Precautions & Warnings

Caution is advised in patients with: Active or suspected peptic ulcer or gastrointestinal bleeding. Moderate to severe hepatic, cardiac, or renal impairment. A history of asthma, dizziness, or urticaria. Patients should be advised to take the medication after meals and report any unusual symptoms such as black stools, abdominal pain, or skin rash.

Use in Special Populations

The safety and efficacy of A-Pak 100 mg in children have not been established due to insufficient clinical data.

Therapeutic Class

Drugs for Osteoarthritis, Drugs for Rheumatoid Arthritis, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

Storage

Store in a cool, dry place, away from direct sunlight and heat. Keep out of the reach of children.